Antibacterial mechanism of chitosan and its derivatives

There are still many unknowns about the antibacterial mechanism of chitosan and its derivatives. According to existing research results, the reason why chitosan and its derivatives can antibacterial is mainly because they react with the bacterial cytoplasmic membrane to a certain extent, destroying the normal physiological functions of the bacteria. Despite this, there are still certain differences in the antibacterial mechanisms of chitosan and its derivatives.

Nbio natural chitosan’s five major antibacterial effects

Product pictures come from

Chitosan’s antibacterial mechanism: The cations carried by chitosan combine ionically with the sialic acid or phospholipid anions that constitute the cell wall of microorganisms, which restricts the freedom of microorganisms and hinders their development. Chitosan is also decomposed into low molecules, which penetrate into the cell wall of microorganisms and hinder the transfer of genetic factors from DNA to RNA, thereby preventing the development and reproduction of microorganisms. The small growth-inhibiting concentration for Escherichia coli (ATCC 11229) and Glucobacter aureus (ATCC 6538) among bacteria is 10~20mg/kg, and the small growth-inhibiting concentration for Botrytis cinerea and spot pathogen is 10mg/kg, both of which show that Extremely high antibacterial properties.

Mechanism of antibacterial effect of chitosan derivatives: According to reports, the target of cationic disinfectants is the cell membrane of microorganisms. The main components of the cell membrane are membrane proteins and phospholipids. The phospholipid of bacteria is glyceryl phosphate, which There are both hydrophilic and hydrophobic ends. Taking quaternary ammonium salts as an example, since the long alkyl chain of chitosan quaternary ammonium salts is also hydrophobic, the strong reaction between chitosan quaternary ammonium salts and phospholipids due to hydrophobic affinity destroys the bacterial cytoplasmic membrane. This results in higher antibacterial activity.

Expansion: (Contact 139-2216-6891 for details)

Nbio natural chitosan’s five major antibacterial effects:

1.Antibacterial property: >99.9% (ATCC 6538, ATCC 4352);

2.Deodorization: >90%-70% (Ammonia Gas test tube method);

3.Far infrared ray (improves human rhythm stability and blood circulation);

4.UV protection: >90% (UV-B KSK 0850);

5.Anti-static: <500 volt (anti-fouling function: anti-dust, anti-pollutant, body rhythm can be stabilized ).