Antibacterial mechanism of chitosan and its derivatives

关于壳聚糖及其衍生物的抗菌机理尚有诸多未明之处。根据现有的研究结果，壳聚糖及其衍生物之所以能够抑菌，主要是由于它们与细菌的细胞质膜发生了一定的反应，破坏了细菌正常的生理功能。尽管如此，壳聚糖及其衍生物在抗菌机理上还是存在一定的差异。

(1)The mechanism of antibacterial effect of chitosan: the cations carried by chitosan and the sialic acid or phospholipid that constitute the microbial cell wall Plasma anions undergo ionic bonding, which restricts the freedom of microorganisms and hinders their development. �壳聚糖还被分解成低分子，渗透到微生物细胞壁内，阻碍遗传因子从DNA到RNA的转移，从而阻止微生物的发育和繁殖� �对细菌中的大肠杆菌、金黄色葡萄糖菌的小发育阻止浓度为10~20mg/kg，对灰霉菌、斑点病菌的小生育阻止浓度为10mg/kg，均显示出极高的抗菌性� �</p

Mechanism of antibacterial effect of chitosan derivatives: According to reports, the target of cationic disinfectants is the cell membrane of microorganisms. The main components of the cell membrane are membrane proteins and phospholipids. The phospholipids of bacteria are phosphoglycerides, which have both hydrophilic ends and Has a hydrophobic end Taking quaternary ammonium salts as an example, since the long alkyl chain of chitosan quaternary ammonium salts is also hydrophobic, the strong reaction between chitosan quaternary ammonium salts and phospholipids due to hydrophobic affinity destroys the bacterial cytoplasmic membrane. resulting in higher antibacterial activity